In 1839, the Republic of Texas relocated its capital to Austin. The town suffered another setback that year when a yellow fever epidemic claimed about one life out of every eight residents. Yet it persisted as a commercial center, forming a symbiosis with its Gulf Coast port, Galveston. Landlocked farmers brought their produce to Houston, using Buffalo Bayou to gain access to Galveston and the Gulf of Mexico. Houston merchants profited from selling staples to farmers and shipping the farmers' produce to Galveston.[11]
Houston's economy since the late 20th century has a broad industrial base in energy, manufacturing, aeronautics, and transportation. Leading in healthcare sectors and building oilfield equipment, Houston has the second most Fortune 500 headquarters of any U.S. municipality within its city limits (after New York City).[13][14] The Port of Houston ranks first in the United States in international waterborne tonnage handled and second in total cargo tonnage handled.[15] Nicknamed the "Bayou City" "Space City”, "H-Town", and “the 713”, Houston has become a global city, with strengths in culture, medicine, and research. The city has a population from various ethnic and religious backgrounds and a large and growing international community. Houston is the most diverse metropolitan area in Texas and has been described as the most racially and ethnically diverse major metropolis in the U.S.[16] It is home to many cultural institutions and exhibits, which attract more than 7 million visitors a year to the Museum District. Houston has an active visual and performing arts scene in the Theater District and offers year-round resident companies in all major performing arts.[17]
Houston's murder rate ranked 46th of U.S. cities with a population over 250,000 in 2005 (per capita rate of 16.3 murders per 100,000 population).[228] In 2010, the city's murder rate (per capita rate of 11.8 murders per 100,000 population) was ranked sixth among U.S. cities with a population of over 750,000 (behind New York City, Chicago, Detroit, Dallas, and Philadelphia)[229] according to the Federal Bureau of Investigation (FBI). Sabbath-keeper
